Based on breakthrough research conducted at ETH Zurich and now published in Nature's npj Aging, we developed a more effective way to replenish the body's natural collagen levels. The Collagen Activator features Colgevity™ – our patented, 100% vegan collagen precursor complex developed in partnership with leading longevity scientists at ETH Zurich.
Unlike traditional animal-derived collagen peptides which must be broken down into smaller fragments before your body can utilise them, our formula provides the optimised building blocks to boost the body's collagen regeneration for deeper, longer lasting results. The Collagen Activator:
A patented, 100% vegan formula developed with leading longevity experts
in Switzerland, designed to stimulate
your body’s own natural collagen production from within.
Advanced Collagen Stimulation
Powered by Colgevity™ - our patented, plant-based collagen precursor shown to be up to 4x more effective than generic collagen - this formula stimulates your body’s own collagen production for deeper, longer-lasting results.
Improved Texture & Firmness
With Alpha-Ketoglutarate (AKG) and Vitamin C from Acerola Cherry, this synergistic formula supports collagen synthesis and improves skin firmness. Astaxanthin, a powerful antioxidant from microalgae, helps protect against oxidative stress, enhancing skin texture and tone.
Lasting Hydration & Elasticity
Collagen provides the structural framework that holds hyaluronic acid and prevents moisture loss. By restoring collagen levels, the Collagen Activator helps skin retain hydration more effectively - improving elasticity, glow, and firmness, while reducing two key signs of ageing: dryness and collagen breakdown.
Stronger Hair & Nails
Collagen is essential not just for skin, but also for the structural integrity of hair and nails. The Collagen Activator helps reinforce keratin-rich tissues, promoting thicker, shinier hair and stronger, less brittle nails.
Developed through years of research at ETH Zurich, and now validated in a published clinical study in Nature’s npj Aging, Colgevity™ is our patented, 100% vegan collagen precursor designed to deliver a precisely engineered blend of natural amino-acids - a 3-1-1 ratio of glycine, proline, hydroxyproline. Optimised for your body to replenish collagen fibres. Colgevity™ has been shown to activate collagen production up to 4x more effectively than traditional animal-derived collagen supplements.
Acerola cherry extract is one of nature’s richest sources of vitamin C, a vital nutrient essential for the body’s collagen production. Acerola extract protects the skin from oxidative stress, supports skin cell health, and helps keep the skin smooth and resilient4.
AKG is a key molecule in cellular metabolism, naturally present in small amounts in protein-rich foods. It plays an important role in collagen synthesis by supporting fibroblast activity and providing metabolic energy required for collagen formation. In addition, AKG helps reduce inflammation and supports cellular self-repair by limiting oxidative stress3.
As one of nature’s most powerful antioxidants, Astaxanthin reduces inflammation and helps protect the skin from oxidative stress2, especially from UV damage. Astaxanthin, typically found in microalgae, also preserves collagen by blocking collagen-degrading enzymes and enhances the skin’s defences against environmental damage.
Developed in Switzerland
Formulated by scientists
Sustainable Packaging
Clinically proven results
Vegan
Halal
ORANIC EXTRACT® Collagen Activator
Based on breakthrough research conducted at ETH Zurich and now published in Natures npj Aging, we developed a more effective way to replenish the body's natural collagen levels. The Collagen Activator features Colgevity™ - our patented, 100% vegan collagen precursor complex developed in partnership with leading longevity scientists at ETH Zurich.
Unlike traditional animal-derived collagen peptides which must be broken down into smaller fragments before your body can utilise them, our formula works upstream to activate the body’s own regenerative processes for deeper, longer lasting results:
Colgevity™ delivers the three essential amino acids - glycine, proline, and hydroxyproline - in the precise ratio required to stimulate collagen synthesis at the cellular level. This patented, 100% vegan complex has been shown to be up to 4x more effective than standard collagen peptides.
Acerola Cherry Extract provides a potent, highly bioavailable source of natural vitamin C – essential for collagen production – while helping protect against oxidative stress and support skin smoothness.
Alpha-Ketoglutarate (AKG) is a longevity-associated molecule that supports cellular energy metabolism and natural collagen formation. It also helps reduce inflammation and promote tissue repair.
Astaxanthin, one of the most powerful antioxidants found in nature, is derived from microalgae. It helps protect the skin from UV-induced damage and oxidative stress, which are both major contributors to collagen breakdown and premature ageing.
Together, these ingredients work in synergy to stimulate natural collagen production, restore firmness and elasticity – while also supporting stronger hair and nails over time.
FLAVOUR
3-month supply delivered every 3 months, charged annually
Pause or cancel at any time
Take one daily Collagen Activator sachet dissolved in a glass of water, smoothie or yoghurt, preferably after a meal or 1–2 hours before bed to promote skin rejuvenation and support restorative sleep thanks to its Glycine content.
Developed in Switzerland
Formulated by Experts
Sustainable Packaging
Clinically proven results
Vegan
Halal
Active ingredients: Colgevity™ 8,400 mg (L-glycine 5,000 mg, L-hydroxyproline 1,700 mg, L-proline 1,700 mg), Calcium Alpha-ketoglutarate 1,000 mg, Algae Powder 200 mg (as Astaxanthin 4 mg), Acerola fruit juice extract 150 mg (provides vitamin C 48 mg)
Other ingredients:
This product may be right for you if:
Our formulations are based on cutting-edge Longevity research. Led by Chief Science Officer Sophie Chabloz, our team collaborates with longevity experts from top institutions to create highly effective, science-backed products.
At AVEA, we prioritise transparency and quality. We develop and manufacture the finished products with globally sourced raw materials in state-of-the-art, GMP-certified facilities in Switzerland that are regularly audited by authorities. Every batch is rigorously double-tested for purity by an independent Swiss lab. We go beyond standard labelling to provide detailed information, and our customer service team is available for any questions or test result requests.
| Active ingredients | Supplier | Production method |
|---|---|---|
| L-Glycine | Xi'an SLT Biotech Co., Ltd. | Chemical synthesis |
| L-Hydroxyproline | Xi'an SLT Biotech Co., Ltd. | Glucose Fermentation |
| L-Proline | Xi'an SLT Biotech Co., Ltd. | Corn fermentation |
| Calcium Alpha-Ketogluterate | Botanic Healthcare Pvt Ltd. | Chemical synthesis |
| Algae Powder | Healthpath Ltd. | Algae fermentation |
| Acerola Fruit Juice Extract | Vidya Herbs Pvt. Ltd. | Acerola fruit juice extraction |
SKIN LONGEVITY BASICS
Most conversations around skin ageing acknowledge collagen loss, but few explore what it really means, or the solutions available to address it. Collagen is the body’s primary structural protein which forms the scaffolding which gives skin its firmness, elasticity and smooth texture.
Unfortunately, from our mid-20s, natural collagen production begins to decline by about 1% each year, accelerating in our 40s, and compounded by external stressors such as UV exposure and oxidative damage.
This combination of slowed production and increased breakdown weakens the skin’s internal structure, leading to visible signs of ageing.
Collagen is one of the most vital structural proteins in the body, responsible for keeping skin firm, elastic, and resilient. Yet most collagen supplements fail to deliver meaningful results - not because collagen doesn’t work, but because it only works if it's provided in a form that the body can actually use.
Traditional collagen products often rely on hydrolysed animal collagen: large protein fragments that must be broken down and absorbed before they can be used by the body. While these peptides can provide raw materials, their biological impact is limited as the body doesn’t automatically recognise them as a signal to produce more collagen, and in many cases, they are diverted to other functions like general protein metabolism, offering little benefit to the skin.
A peer-reviewed study published in Nature's npj Aging confirms this gap: for collagen renewal to occur, the body requires specific amino acids, in a precise ratio, delivered with the correct biological signal. To effectively trigger collagen synthesis, three elements are essential:
When these components are missing or imbalanced, the body lacks both the building blocks and the biological instructions needed to produce strong, stable collagen. This is where many supplements fall short - they may supply fragments but fail to engage the skin’s natural regeneration process.
Most formulas in the collagen supplement space are built on the assumption that simply consuming animal-derived collagen peptides will lead to collagen renewal. In reality, this approach does not account for how the body actually processes collagen.
A peer-reviewed study published in Nature’s npj Aging, shows that collagen synthesis is far more efficiently supported by delivering a targeted blend of the three naturally occurring amino acids that form collagen - glycine, proline, and hydroxyproline - rather than whole collagen peptides.
In the study, this amino-acid composition stimulated natural collagen production up to four times more effectively than traditional animal-derived collagen.
Guided by these findings, and developed in collaboration with longevity scientists from ETH Zurich, the Collagen Activator features Colgevity™, our patented, 100% vegan collagen precursor designed to actively stimulate the body’s own collagen-building processes, together with added co-factors for deeper effects:
The foundation of the formula is Colgevity™ - a patented vegan collagen precursor that provides the three key amino acids (glycine, proline, and hydroxyproline) in the precise ratio needed for collagen synthesis. Unlike hydrolysed collagen, which is often broken down before reaching the skin, these building blocks are readily used by fibroblasts to produce new collagen more efficiently, thus helping restore skin volume, structure, and strength.
Acerola cherry extract, a potent natural source of vitamin C, supports collagen cross-linking and protects skin cells from oxidative damage. Together with Alpha-Ketoglutarate (AKG) - a longevity compound that fuels cellular repair - this duo helps improve skin’s elasticity, promote smoother texture, and restore hydration balance at the structural level.
As collagen production slows, skin begins to lose its firmness and smooth appearance. The Collagen Activator works to restore dermal density by stimulating natural collagen synthesis and reducing inflammation - two critical processes for maintaining depth and preventing the formation of fine lines. The result: visibly firmer, more youthful-looking skin over time.
The Collagen Activator provides key amino acids such as Proline, which not only support collagen formation but also contribute to the structure of keratin-rich tissues like hair and nails. Combined with nutrients that enhance tissue repair and integrity, it promotes visibly stronger, less brittle nails and thicker, shinier hair, thus offering a holistic approach to beauty and structural health.
Collagen is essential for maintaining skin firmness, elasticity, and structure, but supporting skin longevity doesn’t stop at collagen production alone.
Our Collagen Activator is designed to stimulate collagen synthesis directly at the source using Colgevity™, a patented vegan precursor that delivers the exact amino acids needed to form new collagen. Combined with key cofactors like Acerola Cherry (Vitamin C), Alpha-Ketoglutarate (AKG), and Astaxanthin, it helps reactivate the skin’s natural ability to rebuild its internal scaffolding - thus restoring firmness, improving texture, and strengthening hair and nails over time.
SkinSpan™, on the other hand, addresses what causes collagen to break down in the first place. As the skin barrier weakens with age, moisture loss increases, cell renewal slows, and collagen becomes more vulnerable to breakdown. SkinSpan™ reinforces the skin barrier, restores deep hydration, and supports regenerative turnover – creating the ideal conditions for preserving collagen and enhancing the effects of collagen-boosting interventions.
Together, these formulas offer a comprehensive approach to skin longevity:
By combining both, you address not just one part of the skin ageing equation, but all of it, thus helping your skin stay firm, smooth, and resilient over time.
While improved collagen levels are essential for maintaining skin firmness, elasticity, and structure, preserving existing collagen is just as important as producing more of it.
CLINICALLY BACKED FORMULA
noticed improved skin quality
in just 30 days
increase in skin hydration in
just 30 days
year reduction in biological
age after 6 months measured
with TruMe Labs Biological
Age test
more effective than standard
collagen supplements
Colgevity™ is a patented vegan collagen precursor which effectively boosts collagen production, with ETH Zurich studies showing superior conversion compared to conventional supplements. The changes can be measured using VISIA® skin analysis technology, which tracks improvements in texture and hydration.
After 1 month:
Enjoy visibly smoother, more hydrated skin in just one month. Experience a healthy glow, improved moisture levels, and notice stronger nails and hair.
After 3+ months:
Users report noticeable improvements in overall skin quality, including smoother-looking fine lines and wrinkles. Often hair and fingernails start to grow faster.
After 9+ months
Collagen levels in cells are now at a more youthful level. Firmer skin, stronger hair and nails and even improved joint mobility are the typical results seen at this stage.
*Based on customer surveys and scientific literature. Results may vary.
This study was designed to evaluate the effects of Oranic Extract’s Collagen Activator on key skin-related parameters under real-life conditions.
Participants supplemented daily for 30 days, following the recommended dosage. The goal was to assess how a targeted blend of collagen-supporting nutrients may influence skin appearance and overall skin vitality.
The study included adult participants across multiple age groups, with the majority between 30 and 60 years old. Both women and men were represented.
This demographic reflects the audience most commonly seeking support for skin hydration, elasticity, and visible signs of skin aging.
Participants were asked to self-evaluate multiple skin parameters before and after 30 days, including:
Assessments were conducted under everyday conditions to better reflect real-world use.
After 30 days of consistent use:
These results indicate that targeted nutritional support may help promote skin vitality and collagen-related skin functions over time.
The Collagen Activator formulation combines clinically studied nutrients and essential amino acids known to support the body’s natural collagen synthesis processes.
Rather than supplying collagen directly, the formula is designed to provide the building blocks and cofactors required for endogenous collagen production, helping to support skin structure from within.
For full scientific details, methodology, and references, please refer to the complete study documentation .
Our formulations are based on cutting-edge Longevity research. Led by Chief Science Officer Sophie Chabloz, our team collaborates with longevity experts from top institutions to create highly effective, science-backed products.
| Ingredients | Benefits | |||||||
|---|---|---|---|---|---|---|---|---|
| Supports healthy collagen production | Promotes healthy skin elasticity and hydration | Supports the skin’s natural resilience to environmental stressors | Promotes the body’s natural antioxidant processes | Supports healthy joint function | Promotes physical vitality during aging | Supports healthy mitochondrial function and energy production | Promotes vitality and healthy aging processes | |
| L-Glycine / L-Proline / L-Hydroxyproline |
Karna et al., 2020 Chen et al., 2023 |
Al-Atif, 2022 Proksh et al., 2013 |
— | Ruiz-Ramirez et al., 2014 |
Clark et al., 2008 Bello and Oesser, 2006 Moskowitz, 2000 Benito-Ruiz et al., 2009 |
Haus et al., 2007 Bisset and Howlett, 2022 Rene et al., 2017 |
Bannai et al., 2012 | Brind et al., 2011 |
| Alpha-Ketoglutarate | Son et al., 2007 | — | Son et al., 2007 |
Shahmirzadi et al., 2020 He et al., 2017 He et al., 2018 |
Filip et al., 2007 |
Shahmirzadi et al., 2020 Chin et al., 2014 Rhoads and Anderson, 2020 Bisset and Howlett, 2022 Wang et al., 2020 |
Zdzisinska et al., 2016 Bayliak and Lushchak, 2020 Shahmirzadi et al., 2020 Chin et al., 2014 |
Shahmirzadi et al., 2020 Chin et al., 2014 Demidenko et al., 2021 |
| Astaxanthin | Chou et al., 2020 |
Manzanaris et al., 2021 Tominaga et al., 2017 Yamashita, 2009 Tominaga et al., 2012 |
Davnielli et al., 2018 Ito et al., 2018 Li et al., 2020 |
Kohandel et al., 2022 Kim and Kim, 2018 Oh et al., 2020 Kim et al., 2011 Park et al., 2010 |
Sun et al., 2019 | — |
Wolf et al., 2020 Kim and Kim, 2018 Sytretye et al., 2019 |
— |
| Vitamin C (Ascorbic acid) / Acerola (Malpighia emarginata) |
Boyera and Bernhard, 1998 DePhillipo et al., 2018 |
Manzanaris et al., 2021 | — |
Oh et al., 2020 Alvarez-Suarez et al., 2017 |
DePhillipo et al., 2018 |
DePhillipo et al., 2018 Bisset and Howlett, 2022 |
— | — |
|
Oranic Extract's Collagen Activator 
|
Leading Capsule Collagen 
|
Leading Liquid Collagen 
|
Leading Powder Collagen 
|
|
|---|---|---|---|---|
| Collagen source | Vegan Colgevity™ Precursor | Typically animal-derived | Animal-derived | Animal-derived |
| Hydration | 95% improved hydration after one month |
 No proven effects |
No proven effects |
No proven effects |
| Skin Texture | 21% improved skin texture after one month |
No data about skin texture |
No data about skin texture |
No data about skin texture |
| Efficacy & Absorption | The fastest: amino acids, 4x more effective | Slower due to capsule breakdown | Faster, but may degrade in transit | Slower due to collagen breakdown |
| Added Co-Factors | Vitamin C, AKG & Astaxanthin | Typically limited | Usually added | Usually added |
| Longevity Benefits | Clinically based collagen support for longevity |
No proven effect |
No proven effect |
No proven effect |
| Scientific Integrity | Clinically studied, proven effects |
Some are |
Typically limited |
Typically limited |
| Purity & Clean Label | No sugar, fillers, toxins | Often contain fillers | Unwanted additives | Unwanted additives |
| Traceable Ingredients | Vegan, 2x-tested, traceable |
Lacks information |
Lacks information |
Lacks information |
Traditional collagen supplements typically use hydrolysed animal collagen - large protein fragments that must be digested before the body can use them. While they provide generic amino acids, they do not reliably activate collagen production and often lack the biological signals and cofactors needed for true collagen synthesis.
Our Collagen Activator has been developed based on breakthrough research conducted at ETH Zurich and now published in Natures npj Aging, where scientists have discovered a more effective way to replenish the body's natural collagen levels.
It features Colgevity™ - our patented, 100% vegan collagen precursor that delivers the exact three amino acids (glycine, proline, hydroxyproline) in the precise 3:1:1 ratio shown in the peer-reviewed study, clinically proven to be up to 4x more effective than standard collagen peptides.
To support full collagen synthesis, the formula also includes essential cofactors such as Vitamin C, AKG, and Astaxanthin, which help stabilize collagen fibres, fuel cellular repair, and protect the skin from oxidative stress. It is a clean, toxins and sugar-free formula, naturally sweetened with Stevia, and made with traceable, clinically dosed ingredients for maximum effectiveness.
Take one daily Collagen Activator sachet dissolved in a glass of water, smoothie or yoghurt, preferably after a meal or 1-2 hours before bed to promote skin rejuvenation and support restorative sleep thanks to its Glycine content.
The Collagen Activator is designed to help rebuild and maintain the structural proteins that give your skin its firmness, smoothness, and elasticity. Rather than just replacing collagen with generic peptides, it supports your body’s natural ability to produce more collagen - resulting in visibly firmer skin, fewer fine lines, and improved hydration.
It also strengthens hair and nails, thanks to its amino acid-rich formula and targeted micronutrients that support keratin production and tissue repair. It’s a holistic formula designed not just for beauty, but for skin health and longevity.
In an observational human trial with 58 participants (39 women and 19 men), users reported noticeably healthier, more radiant skin within just a few weeks. After only 30 days, 97% noticed an improvement in overall skin quality, and 83% experienced better skin hydration, clear signs of enhanced skin function and moisture balance.
Collagen plays a critical role in maintaining skin structure, elasticity, and resilience. As collagen levels decline with age, the skin begins to lose firmness and moisture, leading to fine lines, dullness, and sagging.
The Collagen Activator helps reverse this decline by supplying the exact building blocks (glycine, proline, hydroxyproline) in the right ratio, while also activating fibroblasts - the skin cells responsible for collagen production. Ingredients such as Astaxanthin protect the skin from oxidative damage, and AKG fuels cellular repair. Together, they help rebuild the skin’s internal scaffolding for a firmer, smoother, and more radiant complexion over time.
We’ve put together our top read articles on collagen below:
Yes, unlike most collagen supplements in the market, our Collagen Activator is a 100% vegan supplement that does not contain any animal-derived ingredients.
Yes, all ingredients in Oranic Extract products are clinically tested and proven safe.
Each active compound – whether in the Collagen Activator or other formulations – is backed by scientific studies that confirm both efficacy and safety. We carefully select the purest and most bioavailable plant extracts and compounds available. Our product descriptions clearly outline the production methods and origins of each ingredient.
Oranic Extract manufactures in state-of-the-art, GMP-certified facilities that are regularly audited by Swiss authorities. Each product batch is sent to an independent Swiss laboratory for additional purity testing, ensuring the highest quality and safety.
The Collagen Activator is free from unnecessary additives – carefully developed to support your long-term health and skin from within.
At Oranic Extract, every formulation begins with a deep understanding of the biological processes that drive ageing and longevity – and how we can influence them. Our work is grounded in the latest findings from the fields of cellular health, metabolic and longevity science.
Led by our Co-Founder and Chief Science Officer, Sophie Chabloz, our in-house science team partners with world-class longevity researchers and biotech experts from leading academic institutions. Together, we translate complex, peer-reviewed research into targeted, effective supplement formulas designed to support cellular function, resilience, and long-term vitality.
Each supplement we create is based on clinically studied ingredients, optimised for bioavailability, and rigorously tested — so that what works in the lab also works in your daily life.
Your supplements will be dispatched from our NL warehouse within 24 hours.
We ship internationally and offer a variety of shipping options:
All available shipping methods — along with estimated delivery times and final costs — will be displayed during checkout.
If your country isn’t listed at checkout, feel free to contact our customer service
The full benefits of supplements take time to develop. Many customers notice initial improvements within the first month, while the full effect typically unfolds after 2–3 months. Since everyone is unique, results may vary. That’s why we recommend following your new routine for at least 3 months.
If you’re not satisfied after this period, you can make use of our 90-day money-back guarantee.
Scientific References
Kohandel, Z., Farkhondeh, T., Aschner, M., Pourbagher-Shahri, A. M., & Samarghandian, S. (2022). Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,145, 112179.https://doi.org/10.1016/j.biopha.2021.112179Manzanares, S., Arias, E.J., Floriach, N., M., S., & Roldán, F.A. (2021). Synergistic antiaging and Dermal Restorative Effects of an Oral Bioactive Procollagen and Astaxanthin Supplement with A Topical Retinyl Palmitate, Vitamin C, Hyaluronic Acid and Alpha Hidroxy Acid Based Regimen.Journal of Dermatology Research. 10.1016/j.biopha.2021.112179
Son, E. D., Choi, G. H., Kim, H., Lee, B., Chang, I. S., & Hwang, J. S. (2007). Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice.Biological & pharmaceutical bulletin,30(8), 1395–1399.https://doi.org/10.1248/bpb.30.1395DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review.Orthopaedic journal of sports medicine,6(10), 2325967118804544.https://doi.org/10.1177/2325967118804544Al-Atif H. (2022). Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics.Dermatology practical & conceptual,12(1), e2022018.https://doi.org/10.5826/dpc.1201a18Alvarez-Suarez, J. M., Giampieri, F., Gasparrini, M., Mazzoni, L., Santos-Buelga, C., González-Paramás, A. M., Forbes-Hernández, T. Y., Afrin, S., Páez-Watson, T., Quiles, J. L., & Battino, M. (2017). The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality.Food & function,8(9), 3250–3258.https://doi.org/10.1039/c7fo00859g
